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Game: Grand Theft Auto: New Leaf
For: Angie Offredi
Location: Little Italy, Heartworks
Target: ISSAC Production Factory
Conditions of mission failure: Wasted
Too many ISSAC bottles destroyed
Nicholas Esposito dies
Reward: $4000
Unlocks: There's a Little Matter We Have to Talk About
Unlocked by: Trucking Feds

Trust ISSAC is a mission in Grand Theft Auto: New Leaf given by Angie Offredi to Tristan Kirby.


Angie invites Tristan to the kitchen as he walks in the door and she explains to him that their drug ISSAC is used to control a person's actions and have them forget after. She tells him that the Uptown Kings - a Spanish-American Street Gang - are planning to attack the Production Factory in Buckingham Park and asks him to protect the factory.

Tristan agrees and leaves to go the factory and meets with Nicholas Esposito and prepare for the attack. After getting in position; they receive word of several Scaffolds arrive as several members of the Uptown Kings begin to attack the factory. They eliminating the first wave of Uptown Kings and the second wave arrives in Deluxo with Special Carbine. They eliminate the second wave and third wave arrives in Froggers. After taking down the helicopters; the Kings stop their attack and Nicholas tells Tristan to leave the area.


  • Go to the ISSAC Production Factory.
  • Get into position.
  • Eliminate the first wave of Uptown Kings.
  • Resupply or stay in position.
  • Eliminate the second wave of Uptown Kings.
  • Resupply or stay in position.
  • Eliminate the third wave of Uptown Kings
  • Leave the factory.


Following the mission Tristan wiil receives $4000.